| Game | Results | Date | Time |
| | RI Storm 10, RI Rampage 8 | Sat Oct 23, 2021 | 9:00 AM |
| | Coventry Crush 9, Wachusett Stars 5 | Sat Oct 23, 2021 | 9:00 AM |
| | EC Scorpions 13, East Bay Rage 3 | Sat Oct 23, 2021 | 9:00 AM |
| | Waves 11, RI Storm 7 | Sat Oct 23, 2021 | 11:00 AM |
| | EC Scorpions 16, RI Rampage 0 | Sat Oct 23, 2021 | 11:00 AM |
| | Wachusett Stars 7, East Bay Rage 2 | Sat Oct 23, 2021 | 11:00 AM |
| | ECS DeMarco 2, SC Rebels 2 | Sat Oct 23, 2021 | 1:00 PM |
| | BNB Rox 8, Maine Thunder 4 | Sat Oct 23, 2021 | 1:00 PM |
| | Coventry Crush 9, WW Warriors 0 | Sat Oct 23, 2021 | 1:00 PM |
| | SC Rebels 6, NE Impact 0 | Sat Oct 23, 2021 | 3:00 PM |
| | Maine Thunder 10, Bay St. Thunder 0 | Sat Oct 23, 2021 | 3:00 PM |
| | Waves 8, Worcester Union 2 | Sat Oct 23, 2021 | 3:00 PM |
| | ECS DeMarco 12, BNB Rox 0 | Sat Oct 23, 2021 | 5:00 PM |
| | WW Warriors 9, Bay St. Thunder 9 | Sat Oct 23, 2021 | 5:00 PM |
| | NE Impact 4, Worcester Union 0 | Sat Oct 23, 2021 | 5:00 PM |
| W02 | SC Rebels 1, Bay St. Thunder 0 | Sun Oct 24, 2021 | 8:00 AM |
| W03 | ECS DeMarco 1, Worcester Union 0 | Sun Oct 24, 2021 | 8:00 AM |
| W04 | East Bay Rage 1, Waves 0 | Sun Oct 24, 2021 | 8:00 AM |
| W05 | NE Impact 1, WW Warriors 0 | Sun Oct 24, 2021 | 9:45 AM |
| W06 | Maine Thunder 1, RI Storm 0 | Sun Oct 24, 2021 | 9:45 AM |
| W07 | Coventry Crush 1, RI Rampage 0 | Sun Oct 24, 2021 | 9:45 AM |
| W01 | Wachusett Stars 1, BNB Rox 0 | Sun Oct 24, 2021 | 11:30 AM |
| W09 | ECS DeMarco 1, SC Rebels 0 | Sun Oct 24, 2021 | 11:30 AM |
| W10 | NE Impact 1, East Bay Rage 0 | Sun Oct 24, 2021 | 11:30 AM |
| W08 | EC Scorpions 1, Wachusett Stars 0 | Sun Oct 24, 2021 | 1:15 PM |
| W11 | Coventry Crush 1, Maine Thunder 0 | Sun Oct 24, 2021 | 1:15 PM |
| W12 | EC Scorpions 1, ECS DeMarco 0 | Sun Oct 24, 2021 | 3:00 PM |
| W13 | Coventry Crush 1, NE Impact 0 | Sun Oct 24, 2021 | 3:00 PM |
| W14 | EC Scorpions vs Coventry Crush | Sun Oct 24, 2021 | 5:00 PM |